Autophagy- Intermittent fasting biggest benefit

by - April 21, 2019

Autophagy is a cellular process in which parts of cells are broken down for later use.

Autophagy is essential for maintaining proper cell function and also helps defend cells in the body. Autophagy plays an important role in the prevention and treatment of cancer.

Several studies in mice suggest that autophagy can prevent cancer. These studies show how the absence of autophagy leads to a decrease in tumor suppressor gene levels. Although lower autophagy may allow the initial formation of tumors, it is not the only cause of the growth or spread of malignancies.

Intermittent fasting stimulates the process of autophagy, a process in which the body breaks down old damaged cells and abnormally developing cells in order to recycle their energy content. The autophagy process is part of the innate immune system and uses pattern recognition receptors to identify invaders of viral cells.

It's ability to stimulates autophagy processes limits viral infections and replication of intracellular parasites. This catabolic process helps the body get rid of intracellular pathogens and stop the abnormal development of cancer cells. It is also important to protect the brain and tissue cells from abnormal growths, toxicity and chronic inflammation.

During feeding, when insulin increases, the rate of autophagy is low. During fasting, as insulin decreases, autophagy increases considerably, perhaps five times. Most of the anti-aging effects of calorie restriction and intermittent fasting come from increased autophagy.
A high rate of autophagy is characteristic of young organisms; with aging, autophagy decreases, allowing the accumulation of cellular damage. When you fast intermittently, autophagy rates can be restored to those of a younger person.

Exercise improves insulin sensitivity. Therefore, regardless of the stimulus of fasting, a fit person will see their insulin levels decrease and lipolysis will start faster than that of a person who is not in shape. Low-carbohydrate diets cause a smaller increase in insulin. Therefore, it is likely that a person on a carbohydrate diet will also see a faster decrease in insulin in the range in which it promotes lipolysis and autophagy.

Autophagy is suppressed in case of insulin resistance and hyperinsulinemia. This could be one of the main mechanisms responsible for the detrimental effects of diabetes and obesity.

In some studies, intermittent fasting has been shown to improve cognition, brain structure and neuroplasticity, which can help the brain learn more easily. That said, it was not entirely clear whether autophagy was the cause; In addition, these studies were conducted on rodents. People are not rodents, and we cannot always assume that the benefits will be the same for us humans.

Autophagy deserves special attention because it is the most important metabolic process to select if the goal is to slow down the aging process and promote the performance of the body and brain.

On October 3, the Nobel Assembly of the Karolinska Institute awarded Yoshinori Ohsumi the Nobel Prize in Physiology or Medicine for his discoveries about the mechanisms of autophagy. You do not win a Nobel Prize in Medicine if you do not work on something that legitimately has the potential to change humanity.

Fasting is actually much more beneficial than simply stimulating autophagy. It does two good things. By stimulating autophagy, we eliminate all our old proteins and cellular parts. At the same time, fasting also stimulates growth hormone, which tells our body to start producing new and attractive parts for the body. We are giving our bodies the complete renovation.


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